Meeting Banner
Abstract #3271

Balanced Steady-State Free Procession (BSSFP) for Detecting Resting-State Networks in Rat Brain at 7T

Patrick P. Gao1, 2, Russell W. Chan1, 2, Joe S. Cheng1, 2, Iris Y. Zhou1, 2, Ed X. Wu1, 2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, Hong Kong SAR, China

Resting-state fMRI (rsfMRI) has been increasingly used to study brain function on humans and animals. Currently, most rsfMRI studies adopt the GE-EPI sequence which has a blood oxygenation level dependent (BOLD) contrast. However, GE-EPI is affected by signal dropout and image distortion due to nature of GE and long echo time. These problems become more severe at high field and in regions close to air-tissue interface. Balanced steady-state free procession (bSSFP) imaging is free from these problems. Recently it has been demonstrated to detect BOLD-like activation signals for fMRI. In this study, we investigated the feasibility of using bSSFP to detect resting-state networks.

Abstract PDF Presentation Video

Keywords

activation adopt adult affected agreement analyzed anesthetized animal animals another apparent arrows atlas balanced become believed benefit bilateral biomedical blood bold brain brains bulb china close coil concatenated conducted connectivity contrast cortex covering currently cycling decomposed demonstrating dependent detect detected detecting discarded distortion dropout electrical electronic engineering equilibrium expanded experiment feasibility field filtered free front function gift good gradient heart hong humans increasingly indicate intensity interface interpolated investigated investigation iris laboratory like long masked matrix maximize measured mechanically mechanisms miller monitored nature near networks note olfactory overlaid oxygen oxygenation particularly poor posited preparation previous primary problems processing procession protocol quadrature quality rare rats recently rectal reduced registered reproducibility resolution respectively respiration resting revealed robustly saturation scanner severe similarity since slice steady strongly studies suggested suited surface susceptibility temperature temporal though tissue toolbox unable unless ventilated vessels visual yellow