Meeting Banner
Abstract #3252

Reducing Physiological Effects in Resting State fMRI by Dephasing Blood and CSF Signals

Yongquan Ye1, Ewart Mark Haacke1

1Radiology, Wayne State University, Detroit, MI, United States

It is well known that the intravascular signals contribute about half of the functional contrast at 3T, and physiological effects also contribute to the BOLD signal. Although extensively studied in task/event related fMRI, the role of vascular and physiological effects in resting state (RS) functional connectivity is yet to be fully understood. By implementing flow dephasing with low VENC value, this study aims at estimating the contribution of the intravascular (IV) blood signal and physiological effects to local and long range resting state signal characteristics.

Keywords

accurate activities activity affect aims although amplitude appears around arteries averaging bipolar blood bold brain cardiac cause caused characteristics clustered coherence collected colors components connectivity consents considered contains contrast contribute contribution cool coordinate cortex cover decreases default depending detect detects determine differently diffusion distributed divides draining duration encoding estimating event excitation expected extracted filter filtering flow fluctuation forward fully functional gradients half hand immediately incorrect induced intensity known largely leading lobule local long mainly major maps mechanism micro middle mode model mostly motion motor network networks neuronal normalized obvious oriented original overlaid oxygen oxygenation paired paralleled part passed patterns physiological posterior processed pulsation radiology rather readout reduce reduced reducing reduction regionally regressing related remain removal removed removing resting routine sample seed short significantly since smoothing sparsely spins spontaneous still strength stroke studied studies subjects superior system task template temporal terms thalamus totally typical unanswered uniform variation vary veins venous ventricles volunteers