Meeting Banner
Abstract #3240

Brain Development During Adolescence: Metabolic, Anatomical and Functional Characterisation in Rats

Luisa Altabella1, Francesca Zoratto1, Francesco De Pasquale2, Giovanni Laviola1, Walter Adriani1, Rossella Canese3

1Cell Biology and Neuroscience, Istituto Superiore di Sanita', Rome, Italy; 2ITAB Neuroscience and Imaging, University G. d'Annunzio, Chieti, Italy; 3Cell Biology and Neuroscience, Istituto Superiore di Sanit, Rome, Italy

It is well know that brain undergoes several morphological and functional changes during adolescence, in humans as well as in rodents. Present data provide a deeper view on the metabolic (by 1H MRS), morphological (by DTI) and functional (by functional connectivity) modifications which occur during rodents adolescence. Major metabolic changes occur during late adolescence, while maturation of cortico-limbic loops progresses during the whole adolescence.

Abstract PDF Presentation Video

Keywords

according addition adolescence adolescent ages among analyzed anatomical anatomy animals applied assess association axial biology biomedical blood bold bootstrapping brain brains cell child choline coil collected confidence connected connection connections connectivity consequence considered control coronal correlation cortex decrease decreased deeper dependent derived described detected development diffusion diffusivity duration early every example exploiting finally findings fitting folding form fractional frontal functional functionality generated gradient gradients happen health hemispheres histogram humans important in vivo intensity international interval intervals invasive investigator know late like limbic lipid loops male maps marker matrix maturation metabolic metabolism middle mind ministry modification modifications morphological networks nucleus occur operating orbital outside oxygen package partial plan positioned preliminary press program project protocol quantitative rapid rats reduction related respect respectively resting rodents science seed seeds session several slice slices smith software spatial specifically spectra spin strength structural studied suggest suitable summarized system tail temporal third transmitter undergoes unpaired view volume wise young youngest