Meeting Banner
Abstract #3200

Bias in Diffusion Tensor Tissue Integrity Measures Due to Sum of Squares Reconstruction: Characterization and Retrospective Correction

Ken E. Sakaie1, Kecheng Liu2, Mark J. Lowe1

1Imaging Institute, The Cleveland Clinic, Cleveland, OH, United States; 2Siemens Medical Solutions USA, Inc, Malvern, PA, United States

Diffusion tensor imaging provides quantitative measures of tissue integrity that can be biased by the properties of the noise distribution. Sum of squares is commonly used for reconstructing multi-coil imaging data and exhibits Rician bias for signals near noise floor, leading to substantial bias in diffusivity values. Here, we quantify the bias and demonstrate that a simple but effective correction that can be applied retrospectively.

Abstract PDF Presentation Video

Keywords

adaptive always ameliorates amelioration among anatomical anisotropy annual another applications applied approved arrow assessment attenuation audience basis bias biased blue board brain breaking channel characterization characterize characterized city clinic coil combine comprehensive computationally converge correct correction dashed dataset default defined derived developed diffusion diffusivity diminishing distribution distributions downward dramatically easy effective effectively estimation example experience feature fiber five floor focused focuses fractional framework gradients head histograms host human illustrates impact implement implementation implemented influence institute integrity intensive internal international introduces intuitively isotropic known longitudinal magnitude mapping mark measures medical medicine meeting mostly necessitating noise noisy nonlinear note optimization organization orientations overall particularly practical previous proceedings produces pronounced prospectively protocol quantify quantitative reconstructed reconstruction reduces reductions requires researchers resolution respect retro retrospective retrospectively review scanner scientific self sense simple society software solid solutions spin squares subjects subsequently substantial substantially switched target tensor tissue toward transformational transverse trio typically upgrade upward ways