Meeting Banner
Abstract #3193

Performance Evaluation of Various Numerical Algorithms for a Multi-Compartmental IVIM-Model

Burkhard Mdler1, Volker A. Coenen2

1Neurosurgery, University Bonn, Medical Centre, Bonn, Germany; 2Divison Stereotaxy and MR-based OR Techniques, University Bonn - Medical Centre, Bonn, Germany

Diffusion-weighted MRI (DWI) is a non-invasive imaging technique that detects thermally driven, random motion of water molecules in living tissue and is able to characterize its interaction with cell membranes, macromolecules and potential diffusion barriers. Le-Bihan proposed a bi-exponential model to separate intra- and extracellular diffusion from incoherent motion of water molecules within randomly oriented capillaries IVIM.

Abstract PDF Presentation Video

Keywords

ability able according acquisition adequate advanced advantages although analyzed apparent application applications assessment assist axis best bowel bulk capillaries cardiac cell characterize chem cirrhosis clinical coefficient coefficients comparable compartmental constant context continuous critical curve decay denoted determination differentiate diffusion displaying distribution eliminated equation estimating estimations evaluation even exponential extraction fact falls field fitting fraction fractions function generalized generally generated generic genetic gradient hereby hypothesize imminent incoherent integral interception intra introduced investigating least lies like lists living macromolecules maps medical membranes modalities model molecular molecules mono motion movement much must necessity neurosurgery noise novelty numerical oriented overall part patient performance perfusion posed problem programming proper protocols prudent pulsation pulsed quantitative radiology random randomly realizations regularized relation reliability reliable reproducible robust robustness routines safe semi several simulated simulation simulations slightly solution special spectrum squares start strongly studies substantially suffers superior taking tanner terms thermally tissue toolbox treatment tumors variance variation various water whole