Meeting Banner
Abstract #3145

Improvement of Diffusion Spectrum Imaging Using Bi-Exponential Diffusion Weighting

Kwan-Jin Jung1

1Psychology, Carnegie Mellon University, Pittsburgh, PA, United States

The brain tissue is known to be bi-exponential in diffusion weighting at a high b value. The diffusion spectrum imaging (DSI) employs a wide range of b values with a peak value greater than 5000 and hence the diffusion in DSI should be considered to be bi-exponential. However, the conventional analysis of DSI has not considered the bi-exponential diffusion weighting. The bi-exponential diffusion weighting in DSI has been accounted for by replacing the acquired b with an adjusted b* which can be obtained by a simple nonlinear curve fitting. The bi-exponentially adjusted b* was experimentally confirmed to be effective in improving the fiber tracts particularly through the multiple fiber crossing regions.

Keywords

accounting achieved addition adjusted adjusting among amplitude analyze another applied applies arise arrows artifacts attenuation audience band basis brain calculation coefficient combined comparing compensate components confirmed considered contrast corrected crossing cubes cubic curve decay default dependent described determined developed diffusion distribution drift effective employed enhancement evidence excessive exponential fast fiber fibers fitting function generalized hamming improve improved improvement index intensity intracellular iteratively known marked match measure measuring might modeled modeling models mono motion narrow nonlinear normalized note offsets orientation partial penetrating penetration physical proposed psychology quality radius reduce reducing reduction replace replaced resolution respectively restored sampling scanned seeding shells significantly simple simulated since slow space spatial spectrum step studio subject subjects table target tensor termination threshold tissue tracking tract tracts trans transform trivial understood utilizes vector voluming water white whole wide windowing wise yellow