Meeting Banner
Abstract #3134

Investigation of Diffusion Kurtosis Imaging of the Organ with Plenty of Perfusion/flow Effect

Yuriko Suzuki1, Marc Van Cauteren2

1Philips Electronics Japan, Minato-ku, Tokyo, Japan; 2Philips Healthcare Asia Pacific, Minato-ku, Tokyo, Japan

Diffusion Kurtosis Imaging (DKI) is a method to study the deviation of water diffusion from Gaussian distribution, which has been successfully applied to several brain diseases recently. However, in the organ with plenty of flow, DKI curve fitting is ruined. The aim of study is to define the DKI model which consider perfusion/flow component, and using this model, investigate how the conventional DKI fitting is affected by perfusion/flow. Our study has shown that large perfusion/flow fraction induced lower R2 of fitting, overestimated D and large error of estimated K.

Abstract PDF Presentation Video

Keywords

actual affected altered annual apparent applied assessment best better biological brain calculation care causing cell characterization coefficient compartment compensate component condition conditions correlation curve curves decay define defined detection deviation diagram diffusion dimensionless diseases distribution done drawn electronics error feasible fitted fitting fittings fixed flow fraction function gave goals healthy improved indicates induced investigate investigation japan know kurtosis larger liver longer makes meeting membrane metric might model models molecules neural organ overestimated overestimation pacific parabola patterns perfusion planar plenty potential precise precisely probability proceedings proposed removing respiratory ruined several shape shot simulate simulated simulating smaller special statistical steeper successfully table tissue triggered twenty validate varied vertex volunteer water wrongly