Meeting Banner
Abstract #3121

Numerical Approach for Quantitative BOLD with Vessel Size Estimate Validation on Phantom.

Nicolas Pannetier1, 2, Maja Sohlin3, Thomas Christen4, Lothar R. Schad5, Norbert Schuff1, 2

1Department of Radiology, University of California San Francisco, San Francisco, CA, United States; 2Centre for Imaging of Neurodegenerative Diseases, Veteran Affairs Medical Centre, San Francisco, CA, United States; 3MR centre, Sahlgrenska University Hospital, Goteborg, Sweden; 4Department of Radiology, Stanford University, Stanford, CA, United States; 5Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Heidelberg, Germany

MRI is a powerful tool to investigate the microvasculature. Various techniques benefit from the entanglement of the contrasts that arise within a voxel and provide relevant biomarkers. However, the analysis relies on analytical models that present a discrepancy with Monte Carlo simulations. In this work we present a versatile approach directly based on a numerical model. The approach is evaluated on phantom data where vessels are mimicked by polyamide strings. We compared our model with analytical ones and we demonstrated that this approach could provide a mean to estimate the radius of the vessel without the use of contrast agent (CA).

Abstract PDF Presentation Video

Keywords

accuracy actually adapted affairs agent agreement analytical approaches arise arrow ascribed assessed assisted assumptions benefit best better blood bold built chosen christen classical clinical component computation computer constraint contains contrasts correct corrected correction decay density derived describe designed diffusion diffusivity directly discrepancy displayed distinguish distribution echoes embedded enhance entanglement error evaluated exhibit expected fail field fits fitted fraction furthermore good gradient graph histograms illustrates immersed in vivo inaccurate index indicates individual induced inhomogeneity initialization initialized interfaces lattice lattices lead long lookup maintain match medical medicine medium mimicked mimics minimization model models molecules narrow numerical occupy ones orthogonal outside overcome overestimate oxygenation perturbation phantom phantoms powerful properly pursued quantitative radii radiology radius randomly recent rejected relevant relies removing respectively restricted robustness root sampling seed simulated simulates simulations solution spin spread square strings stroke studies sufficient susceptibility table tends termed tissue tool validation valley various vessel vessels veteran vicinity volume water white wide wise worse