Investigating the Effect of Intra-Voxel Contrast Agent Diffusion on Quantitative DCE-MRI

Keywords

accurate achieved acknowledgments acquisition additional affects agent allowed allowing amount analyze approaches assumed assumes audience black central characteristics coefficient coefficients common concentration consists contrast coupled curve decrease decreasing defined devised dictated differential diffusion dispersion dist distributed distribution distributions divided domain driven dynamic effort element elemental elements enhanced equation error especially estimation evaluation evidence exacerbated finally finite fitting fixed form forward fractions function funding general hence heterogeneous hypothesized importantly inaccurate include increasing indeed indicates indicating initial input inputting instantaneous institute intensity intra introduced investigates investigating known leads legend model note noticeable occur occurs often parameterization perfused perfusion period play poorly practice print problem quantification quantified quantitative quicker radiological radiology rapidly relation relationship reported resolution return returns role sciences similarly simulated simulation specified step subsequently summed system systematically table target temporal theoretical throughout tissue tumors uniform uniformly utilized various varying vascular volume yield