Distinct Effects of the Nuclear Volume Fraction and Cell Diameter on Diffusion Contrast in Tumors

Keywords

acquisitions anders apparent architectures becomes biological brain caused cell cells cellular clinical clinically coefficient combining compartment compartments considered consisting contrast cytoplasm cytoplasmic dale decrease decreases delineation demonstrating despite determinant diagnosis diameter diffusion diffusivity distinct edema effective elevated emphasis even example exchange expand explain explore extracellular fact fail fast findings flair fraction fractions function furthermore geometries goal going grade gradient grant greater hindered histology implications important improved include increasing independent insensitive intracellular intrinsic lack larger leakage length long longer lymphoma magnitude maps marked materials measured membrane model monitoring monotonically moreover narrow nature negligible nuclear nuclei nucleus observation obvious often origin overall overlaid part percent permeability plays plotted poorly post practice press pronounced proportion radiology reduce reduced reduction regime relationship relatively relevant remains respectively response restricted role scales sensitivity separable separate simple simulate simulation simulations simultaneously specifically spectrum spherical step suggest surgical taken termed traditional transverse treatment tumor tumors utilizes volume water white