Meeting Banner
Abstract #2994

Quantification of Macro- And Micro-Vascular Hemodynamics in Cerebral Arteriovenous Malformations During Staged Embolization

Can Wu1, Timothy J. Carroll1, Parmede Vakil1, Sameer A. Ansari2, Bernard R. Bendok2, Hunt Batjer3, Michael Markl1

1Departments of Biomedical Engineering and Radiology, Northwestern University, Chicago, IL, United States; 2Departments of Radiology and Neurological Surgery, Northwestern University, Chicago, IL, United States; 3Department of Neurological Surgery, UT Southwestern, Dallas, TX, United States

4D flow and perfusion MRI were successfully employed to provide quantitative information on both macro- and micro-vascular hemodynamics in AVM patients during embolization. Schematic AVM models were built for macrovascular flow quantification. Contralateral and ipsilateral tissue perfusion was quantified to evaluate the impact of embolization on systemic hemodynamic changes. Spatial co-registration of the 4D flow and perfusion data provides a joint visualization of macrovascular 3D blood flow and microvascular tissue perfusion. The results demonstrate the potential of the joint 4D flow-perfusion MRI method for AVM pre-treatment planning and post-treatment evaluation.

Abstract PDF Presentation Video

Keywords

abnormal addition affect agent alterations angiography arterial arteries artery assess bifurcations biomedical blood brain built cerebral characteristics characterization coded color combined completely complex comprehensive connections cont contrast coverage cycle decreased depict depicting digital direct directly distinct distribution drained draining employed engineering evaluate example excellent exposure failure feeders feeding female flow gated grant gray guides hemorrhagic highly hunt identified illustrates included includes indicating individual induced injected injection injections integrated intervening intra iodine ionizing joint lack limitation limited macro major malformations markers micro modalities model models monitoring neurological noninvasive northwestern note occluded often outcome particle patient patients patterns peak perfusion planning procedures protocol quantification quantified quantitative quantitatively radiation radiology registration removed required resection resolution scale schematic selective since sinus slice southwestern spatial staged steal strokes structures substantial subtraction successfully support surgery surgical surrounding systemic systems targeted timothy tissue traces treatment unclear useful vascular veins velocities velocity venous vessel vessels visualization visualized white years