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Abstract #2991

Measurement of Hemodynamic Parameters in Carotid Occlusive Disease Using Partial Volume Corrected PCASL fMRI

Iris Asllani1, Shazia Dharssi1, Marykay Pavol1, Ronald L. Lazar1, Randolph S. Marshall1

1Columbia University, New York, NY, United States

There is converging evidence that cerebral hemodynamic failure affects cognitive function in carotid artery disease, but inconsistent methods of measuring both the behavioral and the hemodynamic state have hindered this line of inquiry from influencing clinical management. Here, we present preliminary data from patients with 100% carotid stenosis on whom we measured hemodynamic parameters such as baseline and activation CBF as well as arterial transit times (ATT) using PCASL fMRI.

Keywords

absolute account acquisition activation advantages affects amount analyzed application applications arterial asymmetry atrophy availability available bilateral block blocks bold brain briefly carotid cerebral clinical clinically cognitive computation computed condition conditions conjoined consists contain contained contrast control corrected correction correlate crucial currently date defined delay density described detail detailed determine diagnostic disease duration especially evidence example females finger flair flow function goal good gray hand hemisphere hemispheres hemispheric hyper important importantly inadequacy intensities interestingly investigate iris justified kernel labeling maps mask measure measures measuring metabolism minutes modification modified motor much note numbness occlusion occlusive ongoing overall paired panel panels paradigm partial patient patients patterns physiological population post posterior previously prior prove pseudo randomly rather recruitment regressed relevant report reported represent scanner selected separating severity shape significantly simultaneously smoothing spin statistically stroke structural structure subjects substantial symptoms tapping target throughout tissue tool transit unaffected understanding unit useful variability various volume white wide yields