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Abstract #2961

Effects of Propofol on Cerebral Perfusion of White Matter Versus Gray Matter in Pediatric Brain.

Reem S. Awwad1, Wilburn E. Reddick1, Bryan Winter2, Yimei Li2, John O. Glass1, Roland N. Kaddoum3, Zoltan Patay1, Amar Gajjar4, Julie H. Harreld1

1Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States; 2Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, United States; 3Anesthesiology, St. Jude Children's Research Hospital, Memphis, TN, United States; 4Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States

We retrospectively reviewed DSC perfusion MRI of normal-appearing brain in 38 children to investigate whether, as in gray matter (GM), white matter (WM) or GM/WM ratios of CBF or CBV differed between propofol-sedated (IV) and non-sedated (NS) children. Differences in WM CBF & CBV between groups were not the same as in GM. CBVGM/WM did not differ between groups. NS CBFGM/WM > IV in PCA territory only. Age- and weight-related trends of all measures differed between groups. CBFGM/WM and CBVGM/WM, though less variable than GM or WM measures alone, should be used with caution, as age-related trends may differ with propofol.

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Keywords

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