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Abstract #2945

Small-World Brain Networks in Resting State in Typically Developing Children and Adolescents

Minjie Wu1, Alexander Kmicikewycz1, Donatello Arienzo1, Lisa Lu1, 2, Shaolin Yang1, Mani Pavuluri1

1Psychiatry, University of Illinois at Chicago, Chicago, IL, United States; 2Psychology, Roosevelt University , Chicago, IL, United States

Combining rs-fcMRI and graph theory analyses, this study aims to quantitatively characterize the organizational change of functional brain networks in normal development during childhood and adolescence. No significant correlation was found between age and global network metrices (small-worldness or global efficiency). Significant age-related changes were found in local efficiency and degree at node level at right lingual gyrus, left medial orbitofrontal area, pericalcarine, anterior cingulate gyri. These age-related changes in node-level metrices but not global metrices may suggest topological fine tuning of resting state brain networks in children and adolescents.

Keywords

accuracy activation activity adolescents alongside among analyses anterior applying architecture arousal assent auditory axial bandpass biology black blue board bold brain bravo care characterize children coil complex computational connectivity consistently construct correction correlated correlation cost definitive degree density developing developmental disease documented efficiency efficient electric emotion emotions examine examined examining extract facilities features female filtered findings fine fluid frames frequency function functional general global graph graphs handed head health history hundred hypothesized individual informed injury institutional least lingual local male materials matrix medial motion motor negative network networks neural neurological node nuisance organization parent parents participant participants pattern positive preprocessed preserved prior processing progress psychiatric psychiatry psychology qualitatively quantitatively reached reconfiguration reflect regional registration regression regulation relate related removed represents rest resting reveal review scanned scanning slice slices social status strongest structural subject subsequently suggest suggests superior task temporal temporally theoretic theory threshold topological tuning typically vertical volunteers white world years