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Abstract #2922

Effects of Occlusion Duration on Infarct Volume and Tissue Fate in Ischemic Stroke

Qiang Shen1, Fang Du1, Shiliang Huang1, Yash Vardhan Tiwari1, Timothy O. Duong2

1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 2Research Imaging Institute, UT Health Science Center at San Antonio, San Antonio, TX, United States

We evaluated the initial lesion volume 30 mins after stroke and infarct volume at day 2 for multiple middle cerebral arterial occlusion (MCAO) durations in rats. Our results showed that the infarct volumes at day 2 were smaller than the initial lesion volumes at 30 mins after MCAO in 30- and 45-min MCAO groups but larger in 60- and 90-min groups. In the 30-min MCAO group, half the initial ADC lesion was reversed, whereas in the 60- and 90-min MCAO groups, only about 10% of the initial ADC lesion was reversed, and there was a weak dependence on duration.

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Keywords

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