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Abstract #2916

Investigation of the Cytoarchitectural Changes in Ischemic Infarction Using Cerebral Microenviroment Modeling (CMM)

Edward S. Hui1, 2, Jens H. Jensen1, 2, Xingju Nie1, 2, Ali Tabesh1, 2, Maria F. Falangola1, 2, Joseph A. Helpern1, 2, DeAnna L. Adkins3

1Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, United States; 2Dept of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States; 3Dept of Neuroscience, Medical University of South Carolina, Charleston, SC, United States

Diffusional kurtosis imaging (DKI) has been demonstrated to be a promising tool for ischemic stroke assessment. Diffusional kurtosis of ischemic tissue has been shown in prior studies to remain elevated during subacute ischemia, amid pseudonormalization of diffusivity. However, these bulk diffusion metrics lack information on specific microstructural properties such as the sizes, orientations, volume fractions, and diffusivities of prescribed cellular compartments. In this work, we employ a new tissue model, termed cerebral microenvironment modeling (CMM), which generalizes a previously proposed method so that specific microstructural properties of cortical infarction may be obtained with DKI.

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Keywords

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