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Abstract #2911

Effect of APOE4 on Partial Volume-Corrected Diffusion Anisotropy in Patients with AD and MCI&[reg]&[Prime]

Kyung Mi Lee1, Min-Ji Kim2, Chang Woo Ryu2, Ji Seon Park1, Hak Young Rhee3, Eui Jong Kim1, Geon-Ho Jahng2

1Radiology, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea; 2Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea; 3Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea

To prospectively evaluate whether Apolipoprotein E4 (APOE4) carriers were altered in brain diffusion anisotropy compared with noncarriers in Alzheimer disease (AD), mild cognitive impairment (MCI) and cognitively normal (CN) subjects, 25 AD, 25 MCI, and 25 CN subjects were scanned DTI data. Furthermore, we applied a partial volume correction (PVC) method to minimize contributions of cerebrospinal fluid on FA and trace maps. We concluded that regional microstructural changes of brain in APOE4 carriers of AD and MCI subjects were found and application of the PVC should be helpful for accurate evaluation of microstructural changes in cognitive decline patients.

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Keywords

abnormalities accurate acknowledges addition affairs altered among analyzing anatomical anisotropy application applications applied association atrophy blue brain carrier carriers channel characteristics check clinically cognitive coil concerning confirmed considering corpus corrected correction cortical decline decreased dementia demographic despite development diagnostic diffusion dimensional discovery disease encoding enrolled equation especially evaluate evaluated except family finding fluid fraction fractions frontal function gender general genetic genotype grant gray head health helpful hospital impairment importance incomplete index influences interstitial investigation involved johns limited lingual lobe lobes lobule mainly many mapping maps materials matrix medial mental mild ministry mostly neurology paper parametric parietal park partial patients perfusion potential previous processing program project prospectively psychiatry radiology rather reduced reduction reflect reflecting regional related reports risk sample score segment segmented sense several significantly software stage statistical step steps structure studies subject subjects suggested superior system template temporal thalamus threshold tissue tool trace understanding useful volume welfare whether white years young