Meeting Banner
Abstract #2904

Exploring Anterioposterior Differences of Hippocampus Perfusion Response to Physostigmine Using ASL

Xiufeng Li1, 2, Jeffrey S. Spence3, 4, David M. Buhner4, Robert W. Haley4, Richard W. Briggs2, 4

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 2Radiology, UT Southwestern Medical Center, Dallas, TX, United States; 3Clinical Sciences, UT Southwestern Medical Center, Dallas, TX, United States; 4Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States

A substantial literature indicates distinct yet integrated anatomy and function along the longitudinal hippocampus axis. Some diseases also selectively affect anterior-posterior hippocampus regions. A number of rodent studies report cholinergic selectivity along the longitudinal (ventral-dorsal) axis of the hippocampus. Arterial spin labeling studies were performed to explore possible anterior-posterior differences in human hippocampus perfusion response to cholinergic challenge with the reversible cholinesterase inhibitor physostigmine. In agreement with the hypothesis suggested by the animal literature, a trend of larger rCBF response to physostigmine challenge in anterior hippocampus than in the rest of hippocampus was observed.

Abstract PDF Presentation Video

Keywords

absolute according acquisition administered affairs affect afternoon anterior axial axis beyond bias board body bolus challenge chat clinical coil combined components connections content control controlled correspondence counteract covariate covering days delays distortion dorsal duration efferent eleven endorsement errors especially estimating excluding extended eyes fair federal functional generated government grant greater head hemispheres highest histogram human hypothesis improved induced inferior inferred informed infusion inhibitor injected insignificant institutional integrated integrity interactions interval know larger linear literature local longitudinal male maximal measure medical medicine middle minute mode model neurological night noise parallel partial percentage perfusion peripheral physiological plus posterior preliminary prior protocol psychiatric radial reduce referred reflect reports residual resolution response review rodent rodents roughly saline saturation sciences segmentation segments selectively semi separate session sessions since slice slices southwestern spatial specificity statistical studied studies subject subjects substantial suggest suggested suggesting suggests supported system tail taken temporal terms third tips trends trimmed ventral volume whereas