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Abstract #2895

Long-Term Impact of Major Trauma on Brain Network Function in Traumatic Survivors

Mingying Du1, Wei Liao2, Su Lui1, Xiaoqi Huang1, Qiyong Gong1

1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China; 2Central for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, Zhejiang, China

Evidences had showed acute impact on the brain activity and functional connectivity in healthy trauma survivors, however, little is known about the long-term impact of trauma on the brain network function of healthy survivors. The aim of current study was to use graph theory analysis to evaluate the alteration of neural network function in survivors 2-year after trauma comparing with healthy controls without traumatic experience. Our results provide evidence that the major trauma has long-term impact on the brain network function in physically healthy survivors, highlighting the need for long-term evaluation and intervention for trauma survivors.

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Keywords

abnormal activity acute alteration alterations altered although analyzed anxiety association audience better brain central centralities centrality china cognition comparing complex connectivity constructed contribute controls correlated correlation decreased disasters disorders displayed distress earthquake education efficiency evaluate evaluation evidence evidences examine experience focuses frontal function functional generates global gong graph healthy highlighting hospital impact important indicates inferior integrates integration intervention investigate known lead limbic little local long longitudinal major matched matrices metrics motor natural need network networks neural nodal nonparametric ongoing optimally organization parietal permutation physically post previous progression properties psychiatrists psychologists radiologists radiology randomization rating reflect relationship reported responses resting reveal scanned score self shortly significantly suggesting survivors target term theory thresholding topological topologies topology toward transport trauma traumatic understanding underwent west whole world year years