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Abstract #2890

Investigation of Functional Connectivity Changes in Alzheimer Disease Using Degree Centrality

Yong Zhang1, He Wang1, Guang Cao1, Lin Zhang2, Gui-Xiang Zhang2

1GE Healthcare, Shanghai, China; 2Shanghai First People's Hospital, Shanghai, China

This preliminary study investigated functional connectivity changes in Alzheimers Disease (AD) using degree centrality (DC), a novel resting-state fMRI parameter to provide voxel-wise whole brain functional connectivity measurement. Six AD patients and nine age- and gender-matched healthy controls were recruited for comparison. In additional to the deceased DC regions in bilateral hippocampus and frontal lobe observed for normal aging controls and AD patients, the right insular showed increased DC for normal controls but decreased DC for AD patients, which might provide interesting insight into the mechanism of the disease.

Keywords

according accurate adjustment aged aging altered approved array association avoid axial band bilateral brain centrality channel characterized china choice coefficients cognitive coil committee compensatory connectivity consent consistent contained contrast control controls controversies corrected correction correlation covering criteria deceased decline decreased definitions degree dementia developed disease disorder ethical examination filtered frontal functional gender global handed head healthy hospital house implemented included informed insight investigate investigation leading life lobe local many matched matrix mechanism mental middle might mini neurology nine normalization novel numerous often pair participants pass patients people preliminary preprocessing previous program progressive raised realignment recruited reflect required respectively rest resting reveal sample scanner scores seed selected series serve shanghai slice slices software space spatial standardized statistical studies subjectivity subjects superior temporal thirty timing trended volumes warp whether whole wise written years