Meeting Banner
Abstract #2877

An Integrated Resting-State fMRI and DTI Based Connectivity Analysis to Understand Brain Alteration Affected by Alzheimers Disease and Amnestic Mild Cognitive Impairment

Shantanu Majumdar1, David C. Zhu1, 2

1Department of Radiology, Michigan State University, East Lansing, MI, United States; 2Department of Psychology, Michigan State University, East Lansing, MI, United States

Integration of resting-state functional connectivity analysis with the DTI based white matter connectivity analysis can provide overall neuronal connectivity information about the regions of interest involved. In Alzheimers disease (AD) and amestic mild cognitive impairment patients, certain specific brain regions are affected at early stages than other regions. In this work, we present a quantitative analysis of combined functional-structural connectivity to study the changes in certain cortical regions of the brain known to be affected in AD.

Keywords

acceleration address affected alteration analyses anterior artifacts asked averaging axial band blurring brain certain channel clearly coefficients cognitive coil combined combines comprehensive compute conducted connection connectivities connectivity contiguous control correction correlation cortex cortical cortices courses covariance diffusion disease distance distribution dual east eddy education ellipses example explore eyes fast fiber filtered fluid functional gives global gradient gray head healthy help human impairment included indicate induced integrated integrating introduced inversion issue isthmus keep known light linear locations matched matrix meaningful measure metric metrics mild minutes modal mostly motion natl neuronal nuisance occipital open otherwise overall pair pairs parallel plots posterior previous probabilistic probability processed protocol psychology quadratic quantitative radiology ramp recalled recovery registration relax remain removal represent representing resting root sampling scanner scatter seed selected slice slices spatial spoiled square structural studied studies subject subjects suppressed system target terms timing tracking trends unaffected understand understanding view visible volume volumes volumetric white wise