Tissue Cell Fraction (TCF) from Quantitative Sodium MR Imaging Does Not Change with Age in Cognitively Normal Subjects

Keywords

abnormalities acquisition action aerobically aged aging aiming alter analyzed anatomical anatomy approved averaging blue brain calibration cell cells cellular cognitive cognitively compartment compartments compensated compromised concentration consent conserved conserving consistent constant consumes convoluted corrections cortex dashed declines decreased decreases demand densities density dependence derived despite deviations disease distribution distributions elderly energy even evidence expansion expected extra extracellular face fitted fluid flux fraction function gradient gradients gray green highly histogram impairment increasing indicating indicative individual individuals inset intimately intra ions isotropic known larger linked loss maintain maintained maps measure measured medical membrane metabolic mild minute model morphological narrow near neuropsychiatric nominal paper partial pathology patients permeable phantom plotted potassium potential potentials previously probably problems process projection protocol pumped pumps quantitative quantity radial regional require required resolution resolutions resting selected semi separate shrinkage signed sodium spaces spatial still strength subjects supply thereby tissue twisted unless variance variation vertical volume volumes white whole years