Meeting Banner
Abstract #2871

Relationship Between Cardiovascular Health, Cerebral Physiology and Cognition in Healthy Aging

Claudine Jolle Gauthier1, Muriel Lefort2, Sad Mekary3, Laurence Desjardins-Crpeau3, Ccile Madjar3, Louis Bherer4, Frdrique Frouin2, Richard D. Hoge5

1Neurophysics, Max Planck Institute for Cognitive and Brain Sciences, Leipzig, Saxony, Germany; 2Inserm 678, UPMC, CHU Piti Salptrire, Paris, Ile-de-France, France; 3CRIUGM, Montreal, Quebec, Canada; 4Concordia University, Montreal, Quebec, Canada; 5Physiology, CRIUGM/Universit de Montral, Montreal, Quebec, Canada

Arteries throughout the body stiffen with age, but vessel hardening may start at the level of the aorta and progress to other organs, including the brain. Vascular impairment may contribute to cognitive changes observed with aging. Furthermore, it may be that regular exercise acts as a modulator to partially attenuate the effects of age on vascular and metabolic physiology. Here we show imaging results indicative of a link between vascular health at the level of the aorta, the carotids and the brain with measures of cardiovascular fitness and cognition.

Abstract PDF Presentation Video

Keywords

account acquisition acquisitions acts address adults affect affected aging agreement alpha aorta aortic arch arterial arteries artery assessed attenuate augmentation better black blocks blood body bold brain breath cardiopulmonary cardiovascular carotid carotids central cholesterol cognition cognitive continuously contrast contribute correlations cortical cued decline delay descending described determined done dual duration elasticity encoded every exam exercise fitness fraction frontal functional furthermore gender general hardening health healthy heart holds hypertension hypothesis hypothesized identifying impairment implicated included index individual intersection known labeling lifestyle link linked links male matrix measured metabolic minute modified modulate modulator older oxygen parietal partial partially participant participants percent performance perpendicular physiology poorer post preserved pressure progress progression providing pseudo pulsations pulse putative questions reactivity readouts recording regular risk runs sciences seeks series sessions simultaneous since slices spin start stiffen suffer support system table taking task terms throughout tidal turbo underly underwent unprotected vascular velocity vessel vessels vulnerable wave workload years