Varan Govind1,
Anai Cuadra2, Elizabeth Willen2, Catherine Longa2,
Kristopher Arheart3, M. Judy D. Post1, Monica Molina2,
Carmen Velazquez2, Andrew A. Maudsley1, Sulaiman
Sheriff1
1Radiology,
University of Miami, Miami, FL, United States; 2Pediatrics,
University of Miami, Miami, FL, United States; 3Epidemiology ,
University of Miami, Miami, FL, United States
The long term impact of HIV in the CNS and its antiretroviral treatment on proton MR-observed brain metabolites of adults perinatally-infected with HIV are not characterized completely. In this study, a unique whole-brain MRSI method is used to quantitate changes in brain metabolites, N-acetyl aspartate (NAA), total-creatine (Cre) and total-choline (Cho), in a group of adults perinatally-infected with HIV by comparing it to similar data from a matched community control group.