Meeting Banner
Abstract #2689

Surface and Voxel-Based Analysis of Multi-Modal Quantitative MRI for Pre-Surgical Evaluation of Epilepsy Patients

Ali R. Khan1, Maged Goubran1, Sandrine de Ribaupierre2, Terry Peters1

1Robarts Research Institute, London, ON, Canada; 2Clinical Neurological Sciences, Western University, London, ON, Canada

Pre-surgical localization of the epileptogenic zone is challenging with conventional techniques and often diagnostic scans are found to be negative. Quantitative MRI techniques such as relaxometry and diffusion tensor imaging can potentially detect subtle abnormalities through comparison against a healthy control population atlas. Two approaches for this technique, surface-based and voxel-based, are evaluated in performing patient-specific analyses using quantitative T1, T2 relaxometry, and DTI metrics (FA and MD). We show that both methods produce comparable results and can reveal abnormalities in patients with negative MRI findings.

Abstract PDF Poster PDF

Keywords

abnormalities accurate aligning alleviate allow although analyses anterior approaches atlas atlases boundary brain candidates challenging clinical close clusters common comparing complex computation computed control controls conventionally corrected correction cortical counted decrease demonstrating depth described despot detect detecting diagnostic difficulty diffusion discovery discussed distortions distribution drug entire epilepsy epileptic estimation evaluate evaluated fast field filtering folding form free gray healthy hemisphere histological identifying included individual individualized inform investigation involves isotropic issue khan leave lesions limited lobe localizing many mapping maps math metric metrics modal monitoring multidisciplinary negative neocortex neurological often onto operatively outcome patient patients patterns peters population positive prior proportion proved quantitative random reconstructing recruited registered registration replace resection restricted rigid rounds sample sampled scanned sciences score scores seizure selective significance significantly since space spline statistical statistics strategies structural structures subject subjects suitability suite summarize surface surfer surgical tailor targeting temporal tensor third toolbox treatment univariate volumetric western white wise zone