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Abstract #2557

MR Measurement of Alloy Magnetic Susceptibility: Towards Developing Tissue-Susceptibility Matched Metals

Garrett W. Astary1, Marcus K. Peprah2, Charles R. Fisher3, Paul R. Carney4, Malisa Sarntinoranont5, Mark W. Meisel2, Michele V. Manuel3, Thomas H. Mareci1

1Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, United States; 2Physics, University of Florida, Gainesville, FL, United States; 3Materials Science and Engineering, University of Florida, Gainesville, FL, United States; 4Biomedical Engineering, University of Florida, Gainesville, FL, United States; 5Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, United States

Our goal is to develop an alloy that is magnetic susceptibility-matched to brain tissue to create electrodes and cannula that do not distort MR images. We have developed an MR method for measuring magnetic susceptibility and evaluated the method by measuring the susceptibility of copper-tin alloys and comparing the results to SQUID magnetometry. The MR method was evaluated at 4.7 T and 11.1 T and deviated by less than 3.1% from SQUID magnetometry measurements. The MR method is free of geometric and sample-size restrictions associated with SQUID magnetometry and can be implemented at any facility with MR hardware.

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