Meeting Banner
Abstract #2555

Variable Delay Pulse Train for Fast CEST and NOE-CEST MRI

Jiadi Xu1, Nirbhay N. Yadav1, Amnon Bar-Shir2, Craig Jones1, 2, Kannie W.Y. Chan1, Jingyang Zhang2, Piotr Walczak2, Michael T. McMahon1, Peter C.M. van Zijl1

1F. M. Kirby Center, Kennedy Krieger Institute, Baltimore, MD, United States; 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States

We propose a new technique, variable delay pulsed CEST (VDP CEST), which eliminates the need for performing asymmetry analysis in CEST imaging. The scheme involves acquiring images with variable delay times between RF saturation pulses in pulsed CEST, producing a series of CEST images sensitive to the speed of saturation transfer. Subtracting two images or fitting a time series produces CEST and NOE-relayed CEST maps without effects of direct saturation and strongly reduced influence of semi-solid magnetization transfer. This technique, which can provide very short scan times when using a single RF frequency, is demonstrated in vivo on rat brain.

Abstract PDF Poster PDF

Keywords

achieved amide anesthetized another application assigned asymmetry audience bandwidth brain buildup called clarity clean close coil compensate composite conditions conducted consequently contrast cortex curve cycle cyclically cyclops degree delay despite destroy detection direct disease echoes evidenced exchange exchanging experimental extract fast form frequencies frequency function funding generally gradients grants hand horizontal include indicates inhomogeneity instance intensities intensity interfere investigators irradiation johns longer magnetization magnified male matrix mixed mixing mixture mobile muscle named noes noise nuclear offset offsets often oxygen peak peaks peter plotted positive power predominantly preserved problematic procedure processes promising proteins proton protons pulse pulsed pulses quest radiological radiology rapidly rats readout recorded reduced relayed removed residual resonator respectively saturation scale scanner science semi separate separated side significantly skull slice slower slowly solid species spectra spectrum stimulated strength strong stronger strongly subtracting subtraction support suppressed surface symmetric target tissue train transfer transferring transverse type typical variable visible volume water zero