Meeting Banner
Abstract #2547

The Non-Linearity of CEST and MT Signal Combination

Sheng-Min Huang1, Chih-Kuang Yeh1, Fu-Nien Wang1

1Department of Biomedical Engineering & Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan

The interference from magnetization transfer (MT) in chemical exchange saturation transfer (CEST) complicates the issue of quantitative measurement. In this study, we performed both numerical simulation and phantom experiment to identify if linear combining assumption of CEST and MT signal is appropriate. Both our results showed that the mix signal of CEST and MT were overestimated approximately 25% by linear model, which indicates that linear combination fails to describe the relations between CEST and MT signal. Comprehensive study of CEST and MT relationship is needed for reducing the asymmetric MT effect.

Abstract PDF Poster PDF

Keywords

acquisition added adding addition adjusted affect agar aqueous assumed assumption asymmetric biological biomedical black bulk calculation carried catch cautious central chem chemical class coil combination combinations compartment complicate complicates composed computer consistent contrast correlation dash decrease definition describe describing direct eliminate employed engineering environmental equality equals equations evaluated exchange experiment fail field free frequencies frequency function green hampered identical important incorrect intensity interaction interactions interference intrinsic involved irradiation issue linear linearity macro macromolecular magnetization mathematical matrix measured mentioned merging minimize model modeled molecule needed nonlinear normally novel numerical observable outer overestimated period phantom pool portion post power prepared presence previously process processing profoundly protons pure quantitative realistic reception reducing refer remains represents respectively revealed saturation sciences scripts semi separated seven shimming shot simple simulated simulation simultaneous since solid solute solution solve spectra spectrometer spectrum speculated step steps subtraction suggested swept tissue tolerance transfer tube tubes unclear unsaturated verify volume water wave