Meeting Banner
Abstract #2545

A Multi-Echo Length and Offset VARied Saturation (Me-LOVARS) CEST Method

Xiaolei Song1, 2, Jiadi Xu1, 2, Shuli Xia3, Nirbhay N. Yadav1, 2, Bachchu Lal3, Jeff W.M. Bulte, 24, John Laterra3, Peter C.M. van Zijl1, 2, Michael T. McMahon1, 2

1Division of MR Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States; 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 3Department of Neuro-Oncology, Kennedy Krieger Institute, Baltimore, MD, United States; 4Division of MR Research, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States

Chemical Exchange Saturation Transfer (CEST) has become an important method to generate MRI contrast, with applications in the imaging of strokes and cancer. We present an efficient CEST imaging method, named Multi-echo Length and Offset VARied Saturation (Me-LOVARS), which allows acquiring a series of Z-spectra at multiple tsat values, without extra scan time cost. When using Me-LOVARS for imaging mice baring glioblastomas, 3 Z-spectra with saturation length of 0.8sec., 1.6sec. and 2.4sec were acquired, using same time as one conventional Zspectrum. The contrast-noise-ratio of B0-corrected MTRasym maps using Me-LOVARS is also comparable to the conventional method with the same tsat.

Abstract PDF

Keywords

acceleration acquiring acquisition addition additional affects allows amide applications array asymmetric audience averaging back bearing blocks blue brain brains build builds channel chosen coil collecting collection collects concentration contrast control core corrected correction cost currently curves derived detection determined deviation differentiate direct divides division efficient employing enhancing especially estimating events every exchange expected extra fast faster field fitting freq frequencies frequency function functional going grades gradient grant human idea improving in vivo inserts institute interference interpolating john johns larger last length lengths locker long longitudinal look magnetization mapping maps matrix mice minimizing named note nuclear obvious occurring offset offsets oncology optimal optimized original partially penalty peter piecewise polynomial post prep preparation preparative processing promising proton protons pulse pulses quantification quantified radiological radiology read readout readouts receiver researchers respectively retaining saturation scanner science segment series simulations solute song spectra strength studies surface target tissue train transfer transmitter tumor types varied varies volume whole yields