The CEST Effect of Guanidine and Hydroxyl Protons Can Be Used as a Positive Contrast in Ischemia

Keywords

achieved acid acidosis added addition affected alternatively amide amino apparent application applied arginine arises around arrow artery assumed asymmetry audience background benefit besides best black blue bound buffered chemical clear close closer conditions consequently contra contrast decrease decreases decreasing dependence detecting differentiate diminish direct distinct efficiency endogenous equations exact example exchange exchanges experiment exploited exponentially farther five fraction free frequencies frequency function great green hours hydroxyl identify in vivo induced inevitably inhomogeneity inset investigate investigated irradiation labile latter lesion limited magnetization magnitude maps materials measured middle mild mobile modeled modified moreover mostly necessary negative note nuclear offset opposite optimized peak peaks permanent phantom phantoms physiological pink plot pool positive potential power preliminary press protein proton protons proximity pulse quantitative radiology rats reduce reduces reduction residues respectively saline sample saturation selected selection sensitivity severe shorten side simulated spectra spectrum stroke studies super susceptible symbols target tissue titrated transfer tuned underwent utilizing versus water wave