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Abstract #2540

Sulcal and Gyral Crown Cortical Grey Matter Involvement in Multiple Sclerosis: A Magnetisation Transfer Ratio Study

Rebecca S. Samson1, Nils Muhlert2, Varun Sethi2, Claudia Angela M. Wheeler-Kingshott2, Maria A. Ron2, David H. Miller2, Declan T. Chard2

1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, England, United Kingdom; 2NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom

Histopathology has demonstrated extensive cortical grey matter (CGM) demyelination in multiple sclerosis (MS), and suggests that sulcal folds may be preferentially affected, particularly in secondary progressive (SP) MS. We measured sulcal and gyral crown magnetisation transfer ratio (MTR) in MS and healthy control CGM in vivo, and examined associations with clinical status. CGM MTR abnormalities were present in all MS subtypes and were most pronounced in SPMS. However, sulcal was lower than gyral MTR in all groups (including controls) except SPMS, indicating that there is not a clear sulcal predilection for these changes.

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Keywords

abnormalities acquisition addition affine alternative anticipated apparent appear appears applied assess assessed associations audience authors biomedical brain channel chard chart clinical clinically clinicians cohorts common components content control controls correlations cortex cortical crown crowns density detected determine develop difficult disability disease duration excitation expanded expressed flow functional funding global gradient great health healthy hemispheres house identify in vivo indirectly institute inversion investigate involvement italics kingdom lesion lesions like living maps masks measure median meningeal miller much native neurology nine nominal onset overall paced partial particularly pathological pathology patients people post potential prepared prevalence previously primary processes programs progressive prominent pronounced published pulses quantitative queen rather reduce reduced reflected registered registration relapse relapsing relevant reported saturating scale scheme sclerosis score scores segmented serial shaped software space square stage statistical status studies subject subjects subtypes suggested system table target template tend thank throughout tissue tools transfer transform true unit vision volume volumes volunteers windows years