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Abstract #2532

Prospectively Motion Compensated Amide Proton Transfer MRI for Body Oncology

Jochen Keupp1, Guang Jia2, Ivan E. Dimitrov3, Silke Hey4, Michael V. Knopp2

1Philips Research, Hamburg, Germany; 2Department of Radiology, The Ohio State University, Columbus, OH, United States; 3Philips Healthcare, Cleveland, OH, United States; 4Philips Healthcare, Best, Netherlands

Endogenous contrast of exchangeable amide protons of intra-cellular proteins and peptides (amide proton transfer, APT) has been developed sucessfully and applied for first cinical studies in oncology applications. The work up to now has been mostly focused on the brain, with some extensions to e.g. prostate and breast APT. The organs addressed so far are not subject to respiratory motion. Body oncology applications in e.g. liver and kidney are challenging for APT, because the time scale of RF saturation needed for sensitive APT MRI (about 2s) is of the same order as typical respiratory intervals. A basic respiratory triggered saturation transfer technique was previously developed for contrast agent studies in human kidneys. In the current work, this approach was extended for improved stability of the contrast with varying respiratory cycles, scan time efficiency and SAR management. The novel technique was successfully tested in human volunteers with a focus on APT contrast in liver and kidney.

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Keywords

abdomen achieve achieved acquisition amide applications applied around artifact artifacts asymmetry automatic best beyond blood body bowel brain breast cancer challenging channel clinical compensated compensation complete compromised conditions continued contrast control controlled corrected cycle cycles defined defining delay delays delineation detect detection developed diaphragm dual duration efficiency endogenous example extended extension extensions five frequency healthy homogeneous human improved informed inserted interval intervals intracellular kidney kidneys likely liver long magnetization major management mapping mechanism medulla minor mostly motion narrow needed neurology next normalization novel offset offsets oncology organ organs originating outside parallel patterns pelvic peptides perceived period positive prematurely previously prospectively prostate protein proteins proton protons providing pulsation pulse pulsed pulses quality radiology recent reconstruction remain renal reproducible respiration respiratory saturation scale scanner segment segments sensitive shape sharp sharply space stability stable studies subject successfully switched switching system tissue torso tracking transfer transmission trigger triggered urea variable vessels visible volunteer volunteers waiting