Meeting Banner
Abstract #2422

Measuring the Characteristic Topography of Brain Stiffness with Magnetic Resonance Elastography

Matthew C. Murphy1, John Huston1, Clifford R. Jack1, Kevin J. Glaser1, Matthew L. Senjem1, Jun Chen1, Armando Manduca2, Joel P. Felmlee1, Richard L. Ehman1

1Department of Radiology, Mayo Clinic, Rochester, MN, United States; 2Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States

In this work, we present a novel MR elastography pipeline for measuring regional brain stiffness free of edge-related bias and with high test-retest reliability. Repeatability was measured in 10 healthy volunteers, and the results indicated that typical errors for measuring global and regional brain stiffness were <1% and <2%, respectively. Furthermore, the results show that the mechanical properties of the brain follow a characteristic topography. Considering the lobes of the brain, stiffness is greatest in the occipital lobes, followed by the frontal lobes, the temporal lobes and finally the parietal lobes.

Abstract PDF

Keywords

adaptive another approved artifacts atlas atrophy basis beginning beyond bias biases biomedical bottom brain calculating cerebellum characteristic clinic column considering contrast convolution creating curl deep demonstrating develop deviation direct disease diseases displacement distribution done edge encoding engineering ensures equation erosion erosions evaluating every exam example extends finally findings free frontal furthermore global gradient gray greater greatest improving increasing indicate indicates indicative individuals informed introduce inversion investigated isotropic jack just kernel kernels known leave lobe lobes magnitude maps matrix mayo measure measured measures measuring median minutes model modified motion must neurological novel nuclei occipital offsets outlined outside panel parietal particular period physiology pipeline proportion pulse quartic radiology reconstructed reduce refocusing regional registered related reliability remaining repeated respectively retest scanned science sensitivity shear side simulated simulation simulations since smooth smoothing space spaced specificity step steps stiffness subject subjects summarized temporal thick tissue topographies topography traditional true unique variation volunteers warping wave waves white