Meeting Banner
Abstract #2393

In Vivo Optimisation of GABA Measurements in the Hippocampus Using MEGA-PRESS at 3T

Bhavana S. Solanky1, Niamh Cawley2, Anna Graca1, Richard Anthony Edward Edden3, 4, Olga Ciccarelli2, Claudia Angela M. Wheeler-Kingshott1

1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; 2Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom; 3Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; 4F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

GABA is the main inhibitory neurotransmitter. Using MEGA-PRESS editing techniques GABA measurements in many areas of the brain but have been reported mainly limited to large voxels in areas of B0 homogeneity. 1H MRS measures in the hippocampus, which has an important role in memory and cognitive function, are limited due its small size, strong susceptibility changes and the pulsatile flow of cerebrospinal fluid. This study successfully measured GABA in vivo in the hippocampus at 3T using cardiac triggered MEGA-PRESS. A mean value of 1.7mM was found. This protocol allows reliable absolute measures of GABA in the hippocampus.

Abstract PDF

Keywords

absolute acceptable achieve acquisition addition affected agreement allows although appear assess audience auto best biomedical blocks bone brain cardiac careful channel cohorts commonly concentration concentrations confounded coronal datasets density depicting device diseases distinct distortions drawbacks ease echoes editing example exists field fits flow fluid functional good head healthy heavily hence human in vivo indicated indication informed institute investigate john kingdom knowledge largely larger long male measure measured measures medical medicine mega memory metabolite metabolites moist motor needed neurological neurology neurotransmitter occipital overcome overlapped partial patient peak physicists place placement planned poor positioning press previous prominent protocol proton pulse pulses puts quality quantitative queen radiological radiology reflect reflected reflecting rejected reliability reliable remain remaining repair repeat repeated report reported respectively scaled schizophrenia school science sclerosis separate session shim spectra spectral spectrum spreading square still stimulated studies successfully susceptibility susceptible symposium system systems table target thought triggered triggering unit variations volume volunteer water wheeler whereby