Meeting Banner
Abstract #2358

A Novel Method for Magnetization Transfer Ratio Imaging Without Requiring Separate Saturation Pulse

Jeffrey William Barker1, 2, Kyongtae Ty Bae1, Sung-Hong Park, 13

1Radiology, University of Pittsburgh, Pittsburgh, PA, United States; 2Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; 3Bio and Brain Engineering, Korean Advanced Institute of Science and Technology, Daejeon, Yuseong-gu, Korea

We present a new technique for magnetization transfer (MT) ratio imaging that utilizes interslice MT effects inherent to multislice bSSFP imaging to generate MT contrast, which was controlled via an interslice delay (0-8s). We validated the source of contrast on a 4% agar phantom and saline phantom control. We also demonstrated the feasibility of in vivo MTR imaging by acquiring images in the brain of healthy normal volunteers (N = 5, age 24-49). Agar phantom images were homogeneous, and control images were free of contamination. Mean MTR values from all subjects for white and gray matter regions were (31.71.0)% and (21.71.2)%, respectively.

Keywords

accumulate achieved acquisition acquisitions adding addition adjusting agar allow alternating anterior application applying approved asymmetry avoid axial bandwidth barker better bioengineering board brain centric coil contrast contributions control corpus decrease delay descending doped dummy effectively efficient element engineering enlarged excitation expected exploited extend fast feasibility field free frequencies frequency frontal full future generating give gives grad gradient head healthy homogeneous hong illustrate in vivo index initial institutional intensities interleaving irradiation lead linear linearly macromolecular magnetization matrix measures must neighboring novel occurring offsets overlapping oversampling park percent perfusion perpendicular phantom pixel pixels polarity pool positive precession prior protons pulse pulses radiology readout received receives reconstruction recovery representative require requiring resolution respectively rest review saline saturation science select selection separate sequential sets short sign slice slices solutions source space spatially spin start steady steps subject subjects sufficient sung system together train transfer trio typical utilized utilizing validate validated validation varies varying view visibly volunteers water