Meeting Banner
Abstract #2351

Quantitative Comparison of Susceptibility-Weighted Methods in Deep Grey Matter in Multiple Sclerosis

Luca Y. Li1, Cheryl R. McCreary1, 2, Fiona Costello, 3, Richard Frayne, 3

1Seaman Family MR Research Centre, Foothills Medical Centre, Alberta Health Services, Calgary, Alberta, Canada; 2Departments of Radiology and Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada; 3Hotchkiss Brain Institute, Calgary, Alberta, Canada

Accumulation of iron in deep grey matter structures has been shown to correlate with physical and cognitive and dysfunction in multiple sclerosis. MR susceptibility imaging could provide an objective surrogate marker for accumulation of iron. We compared normalized signal, SNR and CNR of the caudate nucleus, putamen, globus pallidus, and thalamus between T2* gradient echo and SWAN sequences on our 3T GE scanner. 13 subjects with multiple sclerosis and 5 healthy controls participated. Results suggest that changes in signal are more distinguishable on T2* GRE.

Keywords

accepted accumulation advantage always analyses angiography applied arch atlas become better blue brain brass central clinical clinically cognitive concentration consistent contrast control controls converted correlate deep desirable detecting detection diagnosis difficult disability discovery disease distinguishable dysfunction easier electric enhancement essential excess family five flirt fluid focusing foothills general gradient gray green health healthy hypothesis identified improves inconsistent inflammatory institute intensities intensity interaction interpret investigating iron isolate larger make makes making masks matrix medical neither nervous neurological noise normalized novel nucleus offer offered offers patient patients pattern patterns physical picture potentially prepared previous progression properties proton qualitative qualitatively quantitative radiology recorded registered related removing resolution respectively role scanner sclerosis seaman sensitive sensitivity separation services shorter significantly slice slick standardized status structural structures subjective subjects suggest summary susceptibility swan system table thalamus though tissues variance ventricle ventricles viewed white