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Abstract #2344

Cortical Activation Induced by Electrical Stimulation in Patients with Multiple Sclerosis and Foot Drop

Bader Aldebasi1, Xia Lin2, Paul M. Glover3, Richard W. Bowtell3, Cris Constantinescu4, Susan T. Francis5

1SPMMRC, School of Physics & Astronomy,, Nottingham, Nottinghamshire, United Kingdom; 2Division of Rehabilitation and ageing, Nottingham, Nottinghamshire, United Kingdom; 3SPMMRC, School of Physics & Astronomy, Nottingham, Nottinghamshire, United Kingdom; 4Division of clinical Neurology, Nottingham, Nottinghamshire, United Kingdom; 5SPMMRC, School of Physics & Astronomy, Nottingham,, Nottinghamshire, United Kingdom

Functional electrical stimulation (FES) is a technique used to elicit ankle dorsiflexion (ADF) movement by electrically stimulating the common peroneal nerve, and used in gait rehabilitation to correct foot drop. Brain activation patterns associated with Active, Passive, Electrical Stimulated (ES) and combined ES plus Active induced ADF of the affected and non-affected leg are compared in ten MS patients. For Active ADF, a significant increase is seen in secondary motor areas for the affected compared to non-affected leg, whilst for ES ADF, significantly reduced activity in the insula and SII is found for the affected leg.

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Keywords

acquisition activation active actively activity addition aetiology affected although amplitude analyzed anatomically angular ankle anterior arch astronomy axial beta block bold brain channel clinical coil combined common comparing conditions correct corrected correlation cortex cortical cues custom damaged defined delivered despite direct directed disability disease displacement division drop dropped duration electrical elicit established except expanded falling female filtered foot footrest formed functional future gait general glover gradient impairment improve inability increasingly individual induced induces initiated injury kingdom legs linear locomotor long longer made male matrix model monitor motor moved movement movements muscle nerve neurology normalized occurs output particularly passive patient patients pattern people phys physics plasticity plus primary projections random realigned recorded recovery reduced reduction reflected regular rehabilitation relapsing response rest scale scanner school sclerosis score secondary sense sensory spatial speed status stimulated stimulating stimulation stimulus strength studies stumbling subject subjects supine table task term throughout trials unilateral visual walking weakness years