Meeting Banner
Abstract #2307

BOLD fMRI Response of the Rat Brain to Hyperosmotic Saline Infusion

Bianca Gonzales Cerqueira1, Glenn M. Toney2, Timothy O. Duong3

1Research Imaging Institute, Univ. of TX Health Science Center, San Antonio, TX, United States; 2Physiology, Univ. of TX Health Science Center, San Antonio, TX, United States; 3Research Imaging Institute, UT Health Science Center at San Antonio, San Antonio, TX, United States

Rat brain BOLD fMRI response to an infusion of alternating isotonic and hypertonic saline was studied. Previous studies have demonstrated that osmosensitive areas of the brain such as the organum vasculosum laminae terminalis can detect small changes in plasma osmolarity and project to the hypothalamic paraventricular nucleus which is involved in sympathetic activation. Increased sympathetic activation is of interest due to its role in many forms of hypertension. There was an significant (p=0.029) increase in average percent change of hypertonic saline (13.79%) compared to isotonic saline (-0.85%) in the anterior medial hypothalamus, which includes osmosensitive areas of the brain. This study demonstrates that non-invasive functional imagining can translated to longitudinal studies of sympathetic activation and hypertension.

Abstract PDF

Keywords

able activates activation activity additional adult advanced allowing alternating anesthetized animal animals anterior appetite application around artery audience barrier bars bifurcation blood bold brain carotid challenge circuits common comp confirm consisting control correlation cross decreased detect developed drinking elevated elucidate essential extracellular forms function future gradient great head health histological holder homeostatic hormone hypertension hypertensive hypothalamic hypothalamus identified inclusion infusion initially inserted institute intensity internal intubated invasive involved isotonic kidneys lack laminae lesion located longitudinal magnet male mammals matrix mechanical medial minute minutes models nerve neuron neurons nucleus occur orally organ patterns percent physiology pituitary planar positioned prevent previous previously project rats reconstructed recordings recruitment regulation release repeated researchers response responses retention role saline salt science scientists secured sensitive shot sinus slice slices spectral studied studies suggest superimposed suture sympathetic systemic target targets thinned thirst tied timothy tooth toward translational treatment trials tubing univ unknown ventilation warranted water width