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Abstract #2269

Resting State fMRI Revealed Differences in Connectivity to Visual Cortex in Premature Infants with Hypercapnic Ventilation

Xiawei Ou1, George Andrew James2, Zhaohua Ding3, Charles M. Glasier1, Raghu H. Ramakrishnaiah1, Jeffrey R. Kaiser4

1Radiology, Arkansas Children's Hospital; University of Arkansas for Medical Sciences, Little Rock, AR, United States; 2Brain Imaging Research Center, University of Arkansas for Medical Sciences, Little Rock, AR, United States; 3Vanderbilt University Institute of Imaging Science, Nashville, TN, United States; 4Pediatrics, Arkansas Children's Hospital; University of Arkansas for Medical Sciences, Little Rock, AR, United States

We performed resting state fMRI study on extremely low birth-weight (ELBW) infants randomized to groups with or without permissive hypercapnia and compared the functional connectivity in the brain to the primary visual cortex. We found decreased inter-network functional connectivity between visual cortex and motor cortex for the hypercapnic infants. Our findings suggest that hypercapnic ventilation may reduce functional connectivity between brain default networks.

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Keywords

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