Meeting Banner
Abstract #2261

Reliability of Intrinsic Networks Over 128 Weeks

Ann S. Choe1, 2, Suresh E. Joel3, 4, Craig K. Jones3, 4, John Muschelli5, Visar Belegu1, 2, John W. McDonald1, 2, Brian S. Caffo5, Peter C.M. van Zijl3, 4, James J. Pekar3, 4

1Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2International Center for Spinal Cord Injury, Hugo Moser Research Institute, Kennedy Krieger Institute, Baltimore, MD, United States; 3Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 4FM Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 5Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States

Understanding the intra-subject inter-session reproducibility of resting-state fMRI over prolonged time periods is essential. A longitudinal dataset of a healthy subject that covers the span of 128 weeks with weekly repeat measures was used to investigate the stability of network spatial distributions and between network connectivity (BNC), which were found to be stable over 128 weeks. This shows that rs-fMRI outcome measures can be used to reliably monitor disease progression and responses to therapeutic interventions. The most spatially stable network was the primary motor network and BNC was most stable between the secondary visual and salience networks.

Abstract PDF

Keywords

allows attention attentional axial better binary biostatistics black blue bottom boxes brain cardiac clinical clustering column columns component components computed conditions connectivity control cord correction correlation correspondence cortex courses covers create crosses default degree derived detection deviation disease diseases dorsal executive explicit exploiting full functional functions gift grants growing half head health healthy hierarchical identical illustrated included independent injury insight institute inter international interquartile interventions intra intrinsic john johns least limitation maps matrices matrix measure measured measures median medicine middle mode motion motor network networks others outcome outliers overlap pair pairs part participant percent percentage preprocessing primary principal progression protocol pulsation quartile radiological reflected regardless registration regular reliability repeat reproducibility requiring resolution respectively resting salience school science score secondary segmentation sense session several similarity since slice slices smoothing software spatial spatially spinal stability stable strong studies subject suited summed tasks therapeutic thresholded together underwent unified variable various visual weekly weeks years