1Radiology,
Stanford University, Stanford, CA, United States
In this paper, we present the first study demonstrating the synchronously spontaneous fluctuations of cerebral blood volume (CBV) in humans by using ultrasmall superparamagnetic iron particle (USPIO) for fMRI (termed ICE-BVI). Consistent with previous methods utilizing BOLD and CBF, CBV demonstrates spontaneous fluctuations that are synchronized within putative resting state neural networks. ICE-BVI provides a new means for studying the mechanisms of spontaneous fluctuations, and may improve the sensitivity of detection of resting state neural networks.