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Abstract #2226

Comparison of Quantitative Cerebral Blood Flow Measured with Bolus Tracking Perfusion MRI and H215O PET in the Porcine Model

Elias Kellner1, Irina Mader2, Michal Mix3, Marco Reisert1, Katharina Frster4, Thao Nguyen-Thanh2, Daniel Nico Splitthoff1, Peter Gall1, Valerij G. Kiselev1

1Department of Radiology, University Hospital Freiburg, Freiburg, Germany; 2Section of Neuroradiology, University Hospital Freiburg, Freiburg, Germany; 33Department of Nuclear Medicine, University Hospital Freiburg, Freiburg, Germany; 44Department of Cardiovascular Surgery, University Hospital Freiburg, Freiburg, Germany

We recently presented a method for the quantitative determination of the arterial input function for bolus tracking perfusion imaging. Here we present evaluation of cerebral blood flow obtained with the new method in comparison with 15H2O Positron-Emission-Tomography (PET) in the porcine model (N=13). In contrast to previous studies, we do not employ any adjustable parameters. The CBF values obtained with both methods correlate significantly, but MRI CBF is systematically lower. Present results create a quantitative basis for discussing the role of delay and dispersion in as well as the principal difference between PET and MRI perfusion measurements.

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