Meeting Banner
Abstract #2218

Optimal Sampling Settings for Reliable Blood Brain Barrier Permeability Quantification Using DCE-MRI, a Monte Carlo Approach

Cecile RLPN Jeukens1, Harm J. van de Haar1, Jacobus F.A. Jansen1, Paul A.M. Hofman1, C. Eleana Zhang2, Julie Staals2, Saartje Burgmans3, Frans RJ Verhey3, Robert J. van Oostenbrugge2, Walter H. Backes1

1Radiology, Maastricht University Medical Centre, Maastricht, Limburg, Netherlands; 2Neurology, Maastricht University Medical Centre, Maastricht, Limburg, Netherlands; 3Alzheimer Centre Maastricht, Maastricht University Medical Centre, Maastricht, Limburg, Netherlands

Using Monte Carlo simulations, we aim to determine the optimal sampling settings for reliable permeability (Ki) and plasma volume (vp) determination: 1) a single temporal resolution, i.e a single sample frequency (&[Delta]t), versus dual temporal resolution, i.e., a high initial sample frequency (&[Delta]t1=2.5s for 1:30min) followed by a lower sample frequency (&[Delta]t2=10s3min), and 2) the scan duration. We find that using a dual temporal resolution protocol and a scan duration of 15-20 minutes allows a reliable Ki and vp determination (5%/95% CI = -/+ 10%) for Ki and vp values down to Ki=0.002 min-1 and vp = 0.01.

Abstract PDF Poster PDF

Keywords

accuracy accurate accurately added additional allowing allows applicability arterial audience axis barrier beyond bias black blood brain cerebral clinical combinations comfort confidence contrast cooperation coverage critical curve degree dependent determination determine diminishes disadvantageous disease dots dotted dual duration dysfunctional enhancement etiology even every expected find fitted flow frequency function furthermore generated graduate hand harm improved improves in vivo initial input intervals jitter late leads leakage limited links longer median medical minutes model neurology next noise optimal output particular patient permeability physicists pivotal plasma play plots precise precision prolonged protocol quantification quantify radiology rapid reduced reliability reliable repeated required resolution role sample sampling saturation scanning settings short simulated simulations slow solid spatial step target temporal tissue typically validate versus vessel volume yielding