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Abstract #2190

Measurement of Bulk Liver Perfusion: Initial Assessment of Agreement Between ASL and Phase-Contrast MRI at 9.4T

Manil Chouhan1, 2, Rajiv Ramasawmy2, 3, Adrienne E. Campbell-Washburn2, Alan Bainbridge4, Jack Wells2, Nathan Davies5, Rosamund Barbara Pedley3, Raj Mookerjee5, Shonit Punwani1, Stuart Taylor1, Simon Walker-Samuel2, Mark F. Lythgoe2

1Centre for Medical Imaging, University College London, London, Greater London, United Kingdom; 2Centre for Advanced Biomedical Imaging, University College London, London, Greater London, United Kingdom; 3Cancer Institute, University College London, London, Greater London, United Kingdom; 4Department of Medical Physics and Bioengineering, University College London, London, Greater London, United Kingdom; 5Institute for Liver and Digestive Health, University College London, London, United Kingdom

Non-invasive liver perfusion measurements could be used to monitor hepatic disease development and provide a functional biomarker for novel therapies. Arterial spin labelling (ASL) has not found extensive utility in the liver, mainly due to its dual vascular supply and susceptibility to respiratory motion. ASL can provide regional perfusion maps whereas with phase-contrast measurements taken in the portal vein can provide a bulk portal perfusion. Previous work has reported mouse liver regional perfusion maps but here we present rat liver ASL validated against phase-contrast measurements.

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