Meeting Banner
Abstract #2166

Robust T2 Measurements for Multi-TI Arterial Spin Labeling

Johanna Kramme1, Matthias Gnther1, 2

1Fraunhofer MEVIS, Bremen, Germany, Germany; 2Faculty of Physics and Electronics, University of Bremen, Bremen, Germany, Germany

Precise arterial spin labeling T2 measurements are challenging because they are influenced by many factors like the choice of crusher gradients, the refocusing flip angle, and the number of fitted echoes. When extended to multi-TI T2 measurements, SNR at longer inflow times can be critical, especially if scan time limits the number of image averages. Here, a robust and reliable multi-TI T2 acquisition and fitting routine is presented that is fast enough to be implemented in clinical routine to determine T2 values for every individual patient. The T2 values could then be incorporate in two compartment models for permeability quantification.

Abstract PDF Poster PDF

Keywords

acquisition adaptive adjusted although always among angels arterial artifacts assigned astronomical averaging background bandwidths bars beneficial blood bottom brain central challenging choice chosen clinical coil combination comparable compartment consent considered contrast contrasts critical decrease decreasing determine determined development deviate deviation directly displayed distribution done echoes encode encoded enough error especially even every excluded exponential extended fair fall fast fitted fitting five general good gradient gradients head healthy human included incorporated increment independent indicate individual inflow influenced informed intensity just labeling least length like longer longest male many maps masks material maximal meeting might minutes models mostly much noise partial particular partition patient perfusion persists physics post precise proceedings protocols pulse quantification ration readout reasonable reduced refocusing reliable representative resolution reveals robust robustness routine routines saturation scheme scientific segmentation selective several shorter simulations spacing spatial spin systems taken though threshold tissue took transfer turbo twice underlining vendor volunteer volunteers water white written