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Abstract #2162

Comparison of Water Excitation Versus Fat Saturation in Perfusion MRI - Effects on Lipid Signal, SNR and CBF

Karthik Prabhakaran1, Ryan D. Hopson1, Mark A. Elliott1, Kosha Ruparel1, Raquel E. Gur1, Ruben C. Gur1, John A. Detre1

1University of Pennsylvania, Philadelphia, PA, United States

The use of frequency-selective fat saturation in EPI based perfusion imaging results in spurious measurements of cerebral blood flow (CBF) if the lipid suppression is poor and inconsistent. Frequency-selective water excitation provided superior lipid suppression and yielded higher CBF measurements when compared to frequency-selective fat-saturation in a spin-echo EPI pseudo-continuous arterial spin labeling (pCASL) application at 3T.

Keywords

account alternating application argument arrow arterial artifact artifacts axial bandwidth better blood brain calculation cerebral channel chemical clearly cohort coil collection consequently contamination continuous contrast control delay described deviation displace encoding estimation estimations excitation excite excited flow fluctuating frequency generally generated gray half head inconsistent inferior john label labeling lipid magnified maps mark medical methodology minimize moreover noise options overall paired pairs partially particularly perfusion persuasive poor position post potential preferable problematic produce produced product protocol pseudo pulse receive residuals resolution respectively reversed saturated saturation scanner selective series sessions sets significantly since skinny slab slice slices solutions spin spurious statistical subject subjects subsample suggest suggesting superior suppression temporal topics train trio uniform version versus water white whole widely