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Abstract #2069

Mapping of Microscopic Diffusion Anisotropy Measures in the Living Human Brain

Marco Lawrenz1, 2, Jrgen Finsterbusch1, 2

1Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 2NeuroimageNord, Hamburg-Kiel-Lbeck, Germany

Double-wave-vector diffusion-weighting experiments with two weighting periods applied successively offer access to microscopic tissue. Thus, they may help to overcome confounds of DTI, e.g. in white matter fibre crossings. But so far, only the angular signal modulation that reflects the presence of microscopic diffusion anisotropy has been detected in vivo. This study extends present experiments to determine rotationally invariant measures of the microscopic diffusion anisotropy introduced recently. With the dedicated direction combination schema experimental signal variations could be reduced which improves the reliability of the measures. Additionally, the rotational invariance and the applicability in full brain white matter are demonstrated.

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Keywords

absolute access acquisition acquisitions added addition additional additionally aimed aims angular anisotropy antipodal appearance appears applicability applied applying background basic beck benefit body brain channel characterize clinical coherence coherent coil combination combinations comparing confounded confounds considered consistent consisting covering crossings dedicated detected deviations diffusion directional disturbing double duration echoes eddy even expected experiment experimental extend extended fiber fractional furthermore gradient gradients gray hamburg head healthy help histogram histograms human icosahedron improves influence informed instance integrity introduced invariance invariant investigate investigated isotropic larger living manufacturer mapped mapping maps mask measure measures medical microscopic minimal minimize minor mixing modulation neuronal noise normalized observable offer orientations orthogonal overcome parallel particular periods phys possibly properties proposed pulse read reduced reflects reliability reliable representative resolution respectively reveals rotated rotational rotationally scale scanner scanners schema schemes similarity slice slices smaller software successively system systems theoretically tissue trio variations vector volunteer volunteers wave weightings white whole yielding young