Meeting Banner
Abstract #2067

Clinical Feasibility of High-Resolution Single-Shot Diffusion Tensor Trace -Weighted (SsTW) MRI

Alexandru V. Avram1, Joelle E. Sarlls2, Raisa Z. Freidlin3, Peter J. Basser1

1Section on Tissue Biophysics and Biomimetics, NICHD, National Institutes of Health, Bethesda, MD, United States; 2National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States; 3Division of Computational Bioscience, CIT, National Institutes of Health, Bethesda, MD, United States

Given the clinical importance of the mean apparent diffusion coefficient (ADC), we revisit strategies for measuring this important parameter in a single scan and propose an optimized solution for achieving high-resolution diffusion tensor trace -weighted imaging with whole brain coverage. Mean ADC maps measured using the proposed method are similar to those obtained using conventional diffusion tensor imaging (DTI), despite the significant scan time reduction. This technique could be uniquely suited to provide a quantitative microstructural assessment in whole-brain and whole-body diffusion MRI applications where motion is problematic.

Abstract PDF

Keywords

acceleration accommodate accurate achieve acquisition address affect almost apparent applications arena artifacts assessments attempts available axis bias biophysics bioscience body brain breath cancer characterizing clinical color commonly computational contributions coverage date decades dependence derived despite development diagonal diffusion disorders distortions division duration eddy efficient enable enables encoded entire evaluate fast feasibility fiber field flipped fluid fractional full good gradient gradients gray health healthy hold impact important importantly impractically induced infant institutes lack light limitations limited long loss mapping matrix measured minimize mother motion national negligible neurological noise optimized orientation orientations parallel partial peter physiological polarities polarity poor populations positive potentially preliminary problematic progression prone propose proposed pulse purple quantifying quantity rapid readout required resolution respectively revisit robustness scanner section sense series shorter shot significantly since slice solution space spatial stroke subject suffered suggesting suited technology tensor throughout tissue trace translate unavoidable uniform uniquely upon validation view volume volunteers weak white whole