Meeting Banner
Abstract #2058

Axon Diameter Distribution (ADD) MRI

Raisa Z. Freidlin1, Evren Ozarslan2, Sinisa Pajevic1, Michal E. Komlosh3, Peter J. Basser3

1NIH/CIT/DCB, Bethesda, MD, United States; 2Radiology, BWH, Harvard Medical School, Boston, MA, United States; 3NIH/NICHD/PPITS, Bethesda, MD, United States

Obtained the axon diameter distribution (ADD) for fascicles in any orientation, anywhere within a brain volume, is based on estimate of an average propagator in each voxel using a 3-D generalization that determines the direction of maximum diffusivity and then estimates the DW signal attenuation profile.

Keywords

accessible acquisitions acute anatomical animal anywhere applications artifact assessments attenuation axis axon axons biology brain brains calculation caused central chem clinic clustering clusters coded coefficients color compartment consecutive consisted consisting constraints corrects density determine determines developed developmental diameter diffusion diffusivity distribution empirically enable energetic entire equipped errors estimating even experimental fascicle fascicles faster feature finite fixed form framework function general generalization generation gradient hardware heavy hindered histological humans impermeable in vivo inherently integrated knowledge known like marmoset materials maximizing measure measured medical minimizing modal model modeling models mono motional much multivariate narrowing necropsy need nervous next nonparametric novel nubs orientation overhead pack packed parametric particular pathological pathways perpendicular peter phys potential predicted previously priori produced profile propagator proportional protocol pulses radiology relatively require residual routine scanned scanners school skewed slices smaller space speed splines statistical stronger subject system systems tailed theoretical throughout towards translated transmit transmitted tubes uniform unlike volume whether white width