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Abstract #2037

An Alternate Strategy for the Quantification of the in Vivo Glutamate/Glutamine (Glx) Peak at 2.35 Ppm

Ravi Prakash Reddy Nanga1, Hari Hariharan1, Ravinder Reddy1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

Quantification of in vivo Glutamate/Glutamine (Glx) peak at 2.35 ppm from 1H MRS is contaminated with NAA, lipids, macromolecule and with Glx peak at 2.13 ppm. This contamination introduces a challenge in Glx quantification. Here, we propose and demonstrate an alternate strategy to quantify the Glx at 2.35 ppm with high reproducibility, in vivo.

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Keywords

absolute acquisition adaptive aged alternate amplitude anatomical approved attached author automated bias bioengineering biomedical black blue board body brain built channel chosen coil combination compensation composite compositions concentrations confounded consistency consisting contamination contaminations correction cortex custom dependent domain drug eddy editing enhanced especially examine exhibits field fitted fitting frequency frontal functions generalized glutamate grant halved head health healthy human implementation in vivo institute institutional integration inversion invert inverted knowledge larger least linear lipids localized locations macromolecular macromolecules maintain metabolite metabolites narrow national normalized often operator package participated peak peaks phantom placement poses position positioned post prior problem processing progress project propose protocol protons providing pulses quantification radiology reduces reproducibility respectively review room routine saved scale scanned scanner selective shim shimming simplifies since slight software spectra spectroscopy spectrum squares studies subject subtraction successful supplied suppressed table tabulated taking temperature thanks traditional twice variability varies varying vendor volunteers water white whole width wise wolf years